Plate 15.286 Thyroid Gland
Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed
Human, 10% formalin,
A. H. & E.; B. periodic acid-Schiff and hematoxylin stains, 612
x.
Follicles: Structural units of the thyroid gland supported and separated by connective tissue. Note variation in size. A single layer of cells forms the follicle. Shape of cells reflects functional activity. Cells in these follicles are cuboidal with central, rounded nuclei, indicating normal activity.
In A, the colloid in the lumen of the follicle is not stained. In B, the colloid is specifically stained red with the periodic acid-Schiff method because of the chemical composition of colloid, which is a glycoprotein-iodine complex (thyroglobulin).
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