Tibia knee joint
Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed
Rat, 10% formalin, A., H. & E., 50 x;
B. Gomori's aldehyde fuchsin, 612 x.
Enclochondral bone formation is a process in which an embryonal type of hyaline cartilage precedes bone formation. In A, a stage in the endochondral ossification in a long bone (tibia) is shown. Note the cartilaginous epiphyseal plate that separates the epiphysis (above) from the diaphysis (below). The epiphyseal plate is the source of new cartilage, which is replaced by bone during growth in length. Note the zone of hypertrophic cartilage within the epiphyseal plate. This is a stage in endochondral bone formation preceding calcification. Islands of formed endochondral bone are seen above and below the epiphyseal plate in the epiphysis and diaphysis. Note the marrow cavity between plates of endochrondral bone in the diaphysis. This cavity is formed by resorption of endochondral bone.
In B, note the characteristic grouping of fibrocartilage cells and their arrangement in rows separated by dense collagenous connective tissue. Adjacent to fibrocartilage, note the hyaline cartilage cells.
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