Developing neutrophils
Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed
Human, air-dried marrow smear, Wright's stain, 1416 x.
Myeloblast: The stem cell of the leucocytic series with lightly basophilic cytoplasm. The nuclei are large and rounded. The chromatin is in the form of moderately coarse interconnected strands. They constitute 0.3 to 0.5 per cent of marrow cells. Myeloblasts increase in leukemia.
Progranulocyte: Also called promyelocyte. It arises and differentiates from myeloblasts. It has large cells; its nuclei are rounded with coarse chromatin. Cytoplasm is basophilic with some azurophilic granules. This cell type constitutes about 4 per cent of marrow cells.
Neutrophilic myelocyte: This arises from progranulocytes. It is smaller, has less basophilic cytoplasm containing differentiated granules and a nucleus with more compact chromatin.
Neutrophilic bands: These are immature neutrophils. The nuclei are horseshoe- or drumstick-shaped.
Neutrophilic metamyelocyte: It has a kidney-shaped nucleus and is not capable of division. It differentiates into mature neutrophilic myelocytes.
Neutrophil (segmented): This is a mature cell. Its nucleus is markedly lobulated. The lobules may be connected with a thin chromatin thread. Chromatin is compact, and there is abundant cytoplasm. Granules in the cytoplasm are small and may be inconspicuous.
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