Plate 10.191 Stomach: Chief and Parietal Cells
Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed
Rhesus monkey,
glutaraldehyde-osmium fixation,
toluidine blue stain, 1416 x.
Chief cells: Most numerous of gastric gland cells. Cuboidal or pyramidal in shape. Nucleus in basal half of the cell Rich in cytoplasmic ribonucleic acid. Synthesizes zymogen granules containing pepsinogen.
Parietal cells: Larger than chief cells, oval or polygonal in shape. Nuclei are spherical and centrally located. Cytoplasm is finely granular due to an abundance of mitochondria. Parietal cells secrete the hydrochloric acid of gastric juice and the antipernicious anemia factor.
Note the cytological detail seen in this 1 µm thin section and compare with Plate 5.
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